GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10935120 | 1 | rs9990351 | chr3:134239191 | ANAPC13 | chr3:134196547-134204865:- | -0.36 | -11.47 | 4.48E-27 | Height |
| THCA | cis | rs10935120 | 1 | rs9990351 | chr3:134239191 | CEP63 | chr3:134204575-134293852:+ | -0.29 | -6.36 | 4.81E-10 | Height |
| THCA | cis | rs1061377 | 1 | rs9990742 | chr4:39121414 | KLHL5 | chr4:39046659-39123828:+ | -0.2 | -5.4 | 1.06E-7 | Uric acid levels |
| THCA | cis | rs1061377 | 1 | rs9990755 | chr4:39121439 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.77 | 1.47E-8 | Uric acid levels |
| THCA | cis | rs4691139 | 1 | rs9991678 | chr4:165885039 | C4orf39 | chr4:165878100-165880273:+ | 0.2 | 5.56 | 4.48E-8 | Ovarian cancer in BRCA1 mutation carriers |
| THCA | cis | rs9992101 | 1 | rs9992101 | chr4:77360431 | CCDC158 | chr4:77234193-77328458:- | 0.18 | 3.83 | 0.000147 | Creatinine levels |
| THCA | cis | rs9992101 | 1 | rs9992101 | chr4:77360431 | FAM47E | chr4:77135193-77204923:+ | 0.14 | 3.58 | 0.000374 | Creatinine levels |
| THCA | cis | rs2273 | 1 | rs9995007 | chr4:76897791 | NAAA | chr4:76831809-76862166:- | -0.35 | -7.07 | 5.45E-12 | Longevity |
| THCA | cis | rs1061377 | 1 | rs9996285 | chr4:39132176 | KLHL5 | chr4:39046659-39123828:+ | -0.2 | -5.72 | 1.9E-8 | Uric acid levels |
| THCA | cis | rs7665090 | 1 | rs9996834 | chr4:103557529 | CISD2 | chr4:103790135-103809913:+ | -0.16 | -3.62 | 0.000321 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs9996834 | chr4:103557529 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.2 | 3.16E-5 | Primary biliary cirrhosis |
| THCA | cis | rs1061377 | 1 | rs9997089 | chr4:39120883 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.77 | 1.47E-8 | Uric acid levels |
| THCA | cis | rs6832769 | 1 | rs9997288 | chr4:56347227 | TMEM165 | chr4:56262090-56292342:+ | -0.15 | -3.69 | 0.000252 | Personality dimensions |
| THCA | cis | rs10518128 | 1 | rs9997663 | chr4:75705378 | BTC | chr4:75671448-75719882:- | 0.21 | 3.95 | 9.15E-5 | Electroencephalogram traits |
| THCA | cis | rs6832769 | 1 | rs9998146 | chr4:56397977 | TMEM165 | chr4:56262090-56292342:+ | 0.15 | 3.71 | 0.000234 | Personality dimensions |